Apparatus and method for estimating bio-information

ABSTRACT

An apparatus for non-invasively estimating bio-information is provided. According to one exemplary embodiment, the apparatus may include a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to extract a plurality of characteristic points from the bio-signal, determine internally dividing points of the plurality of characteristic points, and extract feature values from the bio-signal based on the internally dividing points to perform bio-information estimation.

CROSS-REFERENCE TO RELATED APPLICATION(S)

This application is a continuation-in-part of U.S. application Ser. No. 16/128,060 filed Sep. 11, 2018, which claims priority from Korean Patent Application No. 10-2017-0116935, filed on Sep. 13, 2017 in the Korean Intellectual Property Office, the disclosures of which are incorporated herein by reference in their entireties.

BACKGROUND 1. Field

Apparatuses and methods consistent with exemplary embodiments relate to non-invasively estimating bio-information.

2. Description of Related Art

Research on information technology (IT)-medical convergence technology, in which IT and medical technology are combined, is being recently carried out to address the aging population structure, rapid increase in medical expenses, and shortage of specialized medical service personnel. In particular, monitoring of a health status of a human body is not limited to being performed only at a fixed place, such as a hospital, but is expanded to a mobile healthcare sector for monitoring a user's health status at any time and any place in daily life at home and office. Electrocardiography (ECG), photoplethysmogram (PPG), and electromyography (EMG) signals are examples of bio-signals that indicate the individual's health condition. A variety of signal sensors are being developed to measure such signals in daily life. Especially, in the case of a PPG sensor, it is possible to estimate blood pressure of a human body by analyzing a form of pulse wave that reflects a cardiovascular state.

According to a PPG bio-signal related research, the whole PPG signal is a summation of a propagation wave propagating from the heart to peripheral parts of a body and reflection waves returning from the peripheral parts of the body. It is known that information to be used to estimate blood pressure can be acquired by extracting various features related to propagation waves or reflection waves.

SUMMARY

According to an aspect of an exemplary embodiment, there is provided an apparatus for estimating bio-information, the apparatus including: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to extract a plurality of characteristic points from the bio-signal, determine internally dividing points of the plurality of characteristic points, and extract feature values from the bio-signal based on the internally dividing points to perform bio-information estimation.

The processor may include an internally dividing point calculator configured to apply weights respectively to time values of the plurality of characteristic points and calculate the internally dividing points of the plurality of characteristic points based on the time values to which the weights are applied.

The internally dividing point calculator may be further configured to calculate the internally dividing points of the plurality of characteristic points based on a sum of the weights.

The internally dividing point calculator may be further configured to apply the weights respectively to the time values based on amplitude values of the plurality of characteristic points.

The internally dividing point calculator may be further configured to calculate the weights based on differences between first amplitudes at a plurality of points in a derivative signal of the bio-signal and a second amplitude at a predetermined point in the derivative signal, and wherein the plurality of points in the derivative signal may correspond to the plurality of characteristic points extracted from the bio-signal.

The processor may include a bio-information estimator configured to estimate bio-information comprising at least one of blood pressure, vascular age, arterial stiffness, aortic pressure waveform, stress index, and fatigue based on the extracted feature values.

The processor may include a characteristic point extractor configured to extract, as the plurality of characteristic points, at least one of points associated with component pulses constituting the bio-signal, a point at which an amplitude has a maximum value in a systolic region of the bio-signal, an area of the bio-signal, and a point in a predetermined region of the bio-signal where a first derivative value is closest to zero.

The characteristic point extractor may be further configured to determine local minimum points in a second derivative signal of the bio-signal as the points associated with the component pulses.

The processor may further include a feature extractor configured to extract the feature values based on at least one of a ratio of the area of the bio-signal to an amplitude value at the point at which an amplitude has the maximum value in the systolic region of the bio-signal and a difference in time value between the internally dividing points acquired from each of the systolic region and a diastolic region of the bio-signal.

The bio-signal acquirer may include a photoplethysmogram (PPG) sensor configured to emit a light to an object and acquire a PPG signal by detecting the light reflected or scattered from the object.

The apparatus may further include a communication interface configured to receive a PPG signal from an external device and transmit the PPG signal to the bio-signal acquirer.

The bio-signal acquirer may include a light source configured to emit a light to an object and a detector configured to detect the light scattered or reflected from the object, and wherein the bio-signal acquirer may acquire the bio-signal from the light detected by the detector.

According to an aspect of another exemplary embodiment, there is provided a method of estimating bio-information, including: acquiring a bio-signal; extract a plurality of characteristic points from the bio-signal; determining internally dividing points of the plurality of characteristic points; and extracting feature values from the bio-signal based on the internally dividing points to perform bio-information estimation.

The determining the internally dividing points may include applying weights respectively to time values of the plurality of characteristic points and calculating the internally dividing points of the plurality of characteristic points based on the time values to which the weights are applied.

The determining the internally dividing points may include calculating the internally dividing points of the plurality of characteristic points based on a sum of the weights.

The determining the internally dividing points may include applying the weights respectively to the time values based on amplitude values of the plurality of characteristic points.

The determining the internally dividing points may include applying the weights respectively to the time values based on differences between first amplitudes at a plurality of points in a derivative signal of the bio-signal and a second amplitude at a predetermined point in the derivative signal, and wherein the plurality of points in the derivative signal may correspond to the plurality of characteristic points extracted from the bio-signal.

The method may further include estimating the bio-information, which includes at least one of blood pressure, vascular age, arterial stiffness, aortic pressure waveform, stress index, and fatigue, based on the extracted feature values.

The method may further include extracting, as the plurality of characteristic points, at least one of points associated with component pulses constituting the bio-signal, a point at which an amplitude has a maximum value in a systolic region of the bio-signal, and a point in a predetermined region of the bio-signal where a first derivative value is closest to zero.

The extracting of the characteristic points may include determining local minimum points in a second derivative signal of the bio-signal as the points associated with the component pulses.

The extracting the feature values may include extracting the feature values based on at least one of a ratio of the area of the bio-signal to an amplitude value at the point at which an amplitude has the maximum value in the systolic region of the bio-signal and a difference in time value between the internally dividing points acquired from each of the systolic region and a diastolic region of the bio-signal.

According to an aspect of another exemplary embodiment, there is provided a blood pressure monitoring device, including: a light emitter configured to emit a light to a subject; a light detector configured to detect the light that is scattered, deflected, or reflected from the subject to obtain a pulse wave signal from the detected light; a processor configured to extract a plurality of characteristic points from the pulse wave signal, determine amplitude values corresponding to the plurality of characteristic points from the pulse wave signal, determine an internally dividing point of the plurality of characteristic points based on the amplitude values and the plurality of characteristic points, and determine a blood pressure of the subject based on the internally dividing point of the pulse wave signal.

The processor may be further configured to: extract a first time point T₁ and a second time point T₂ from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a first component pulse wave that has a maximum amplitude at the first time point T₁, and a second component pulse wave that has a maximum amplitude at the second time point T₂; determine a first amplitude P₁ and a second amplitude P₂ of the pulse wave signal corresponding to the first time point T₁and the second time point T₂, respectively; and determine the internally dividing point based on the first time point T₁, the second time point T₂, the first amplitude P₁, and the second amplitude P₂.

The processor may be further configured to: extract a first time point T₁and a maximum time point T_(max) from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a first component pulse wave that has a maximum amplitude at the first time point T₁, and the pulse wave signal has a maximum amplitude P_(max) at the maximum time point T_(max); determine a first amplitude P₁ of the pulse wave signal corresponding to the first time point T₁; and determine the internally dividing point based on the first time point T₁, the maximum time point T_(max), the first amplitude P₁ and the maximum amplitude P_(max).

The processor may be further configured to: extract a third time point T₃ and a fourth time point T₄ from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a third component pulse wave that has a maximum amplitude at the third time point T₃, and a fourth component pulse wave that has a maximum amplitude at the fourth time point T₄; determine a third amplitude P3 and a fourth amplitude P₄ of the pulse wave signal corresponding to T3 and T4, respectively; and determine the internally dividing point based on the third time point T₃, the fourth time point T₄, the third amplitude P₃, and the fourth amplitude P₄, in response to the fourth amplitude P₄ being greater than the third amplitude P₃.

The processor may be further configured to: extract a third local minimum point T_(local3) and a fourth local minimum point T_(local4) from a second derivative signal of the pulse wave signal; extract, from the second derivative signal, a third local maximum point L₃ that appears prior to the third local minimum point T_(local3), and a fourth local maximum point L₄ that appears between the third local minimum point T_(local3) and the fourth local minimum point T_(local4); determine a first difference W₁ between an amplitude at the third local minimum point T_(local3) and an amplitude at the fourth local maximum point L₄; determine a second difference W₂ between the amplitude at the fourth local maximum point L₄ and an amplitude at the fourth local minimum point T_(local4); and determine the internally dividing point based on the third local minimum point T_(local3), the fourth local minimum point T_(local4), the first difference W₁, and the second difference W₂.

The processor may be further configured to: extract a third local minimum point T_(local3) and a fourth local minimum point T_(local4) from a second derivative signal of the pulse wave signal; extract, from the second derivative signal, a third local maximum point L₃ that appears prior to the third local minimum point T_(local3), and a fourth local maximum point L₄ that appears between the third local minimum point T_(local3), and the fourth local minimum point T_(local3); determine a first difference W₁ between an amplitude at the third local maximum point L₃ and an amplitude at the third local minimum point T_(local3); determine a second difference W₂ between the amplitude at the third local maximum point L₃ and the amplitude at the fourth local minimum point T_(local4); and in response to the first difference W₁ being less than a predetermined threshold value, determine the internally dividing point based on the third local minimum point T_(local3), the fourth local minimum point T_(local4), the first difference W₁, and the second difference W₂.

According to an aspect of an exemplary embodiment, there is provided an apparatus for estimating bio-information, the apparatus including: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to determine whether there is an inflection point in a predetermined time range of a second derivative signal of the acquired bio-signal, and upon determining that there is the inflection point, configured to calculate an internally dividing point between the inflection point and a first characteristic point extracted from the bio-signal, and to extract features for bio-information estimation based on the calculated internally dividing point.

In response to there being no inflection point in the predetermined time range, the processor may extract the features for bio-information estimation based on a second characteristic point extracted from the bio-signal.

In this case, the first characteristic point may include a point in a systolic region of the bio-signal where an amplitude has a maximum value, or a point in a predetermined region of the bio-signal where a first derivative value is closest to zero; and the second characteristic point may include a first local minimum point of the second derivative signal of the bio-signal.

The time range may be at least a portion of a time range from a first local maximum point of the second derivative signal of the bio-signal to the first local minimum point thereof.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and/or other aspects will be more apparent by describing certain exemplary embodiments, with reference to the accompanying drawings, in which:

FIG. 1 is a block diagram illustrating an apparatus for estimating bio-information according to one exemplary embodiment.

FIG. 2 is a block diagram illustrating an apparatus for estimating bio-information according to another exemplary embodiment.

FIG. 3 is a block diagram illustrating a processor according to the exemplary embodiments of FIGS. 1 and 2.

FIGS. 4A, 4B, 4C, 4D, and 4E are diagrams for describing an exemplary embodiment in which characteristic points are extracted from a bio-signal.

FIGS. 5A, 5B, 5C, 5D, and 5E are diagrams for describing an exemplary embodiment in which internal dividing points are calculated using the characteristic points of the bio-signal.

FIGS. 6A, 6B, and 6C are flowcharts illustrating a method of estimating bio-information according to one exemplary embodiment.

FIGS. 7A, 7B, 7C, and 7D are diagrams for describing a wearable device according to one exemplary embodiment.

DETAILED DESCRIPTION

Exemplary embodiments are described in greater detail below with reference to the accompanying drawings.

In the following description, like drawing reference numerals are used for like elements, even in different drawings. The matters defined in the description, such as detailed construction and elements, are provided to assist in a comprehensive understanding of the exemplary embodiments. However, it is apparent that the exemplary embodiments can be practiced without those specifically defined matters. Also, well-known functions or constructions are not described in detail since they would obscure the description with unnecessary detail.

It will be understood that, although the terms first, second, etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. Also, the singular forms are intended to include the plural forms as well, unless the context clearly indicates otherwise. In the specification, unless explicitly described to the contrary, the word “comprise” and variations such as “comprises” or “comprising,” will be understood to imply the inclusion of stated elements but not the exclusion of any other elements. Terms such as “ . . . unit” and “module” denote units that process at least one function or operation, and they may be implemented by using hardware, software, or a combination of hardware and software.

Expressions such as “at least one of,” when preceding a list of elements, modify the entire list of elements and do not modify the individual elements of the list.

FIG. 1 is a block diagram illustrating an apparatus for estimating bio-information according to one exemplary embodiment. The apparatus 100 for estimating bio-information of the present exemplary embodiment may be implemented as a hardware device to be mounted in a terminal, such as a smartphone, a tablet personal computer (PC), a desktop PC, a notebook PC, or the like, or an independent hardware device. When the apparatus 100 is implemented as an independent hardware device, the apparatus 100 may have the form of a wearable device that a user (e.g., an object OBJ) can easily measure bio-information while carrying the device. For example, the hardware device may be implemented as a wearable device of a wristwatch type, a bracelet type, a wristband type, a ring type, a glass type, or a hairband type. However, the type of wearable device is not limited to the above examples, and the wearable device may be modified according to various purposes, for example, it may be manufactured as a fixed type for utilizing bio-information in a medical institution for measurement and analysis.

Referring to FIG. 1, the apparatus 100 for estimating bio-information includes a bio-signal acquirer 110 and a processor 120.

The bio-signal acquirer 110 may acquire a bio-signal from an object OBJ as shown in FIG. 1 and transmit the acquired bio-signal to the processor 120. In this case, the bio-signal may be a photoplethysmogram (PPG) signal (hereafter referred to as a “pulse wave signal”). However, the bio-signal is not limited thereto and may include various bio-signals, such as an electrocardiography (ECG) signal, a PPG signal, an electromyography (EMG) signal, and the like, which can be modeled by a plurality of waveform components.

For example, the bio-signal acquirer 110 may include a spectrometer or a PPG sensor configured to measure a PPG signal. The PPG sensor may include a light source configured to emit light to the object OBJ and a detector configured to measure a PPG signal by detecting light scattered or reflected from tissues of the irradiated object OBJ. In this case, the light source may include at least one of a light emitting diode, a laser diode, and a phosphor, but is not limited thereto. The detector may include a photodiode.

The processor 120 may generate a control signal to drive the bio-signal acquirer 110. Upon receiving the control signal from the processor 120, the bio-signal acquirer 110 may emit a light to the object OBJ and receive the light that is reflected from the OBJ. The bio-signal acquire 110 may acquire a pulse wave signal (i.e., a PPG signal) from the received light. The object is a living body which can be in touch with or adjacent to the PPG sensor and may be a part of a human body which is easy to measure a PPG signal. For example, the object OBJ may be an area of a wrist surface adjacent to a radial artery and may include an upper part of a wrist where venous blood or capillary blood passes. When a pulse wave is measured at a skin surface of the wrist under which the radial artery passes, the influence of external factors, such as the thickness of the skin tissue inside the wrist, which cause a measurement error can be relatively small. However, the object OBJ is not limited to the above examples, and may be a peripheral region of a human body, such as a finger, a toe, or the like, which is a region having a high blood vessel density in the human body.

When acquiring the bio-signal, the bio-signal acquirer 110 may perform preprocessing on the bio-signal, such as filtering for removing noise from the acquired bio-signal, amplification of the bio-signal, or converting the bio-signal into a digital signal.

When the processor 120 receives a request for bio-signal estimation from the user, the processor 120 may generate a control signal to control the bio-signal acquirer 110, and transmit the control signal to the bio-signal acquirer 110. In addition, the processor 120 may receive the bio-signal from the bio-signal acquirer 110 and acquire bio-information by analyzing the received bio-signal. In this case, the bio-information may include a blood pressure, vascular age, arterial stiffness, aortic pressure waveform, stress index and fatigue, but is not limited thereto.

When the processor 120 receives the bio-signal from the bio-signal acquirer 110, the processor 120 may extract features necessary for bio-information estimation by analyzing a waveform of the received bio-signal. To this end, the processor 120 may extract a plurality of characteristic points from the received bio-signal and extract the features using the extracted characteristic points.

For example, the processor 120 may extract points associated with a plurality of component pulses constituting the waveform of the entire bio-signal as the characteristic points. In addition, the processor 120 may calculate internally dividing points of characteristic points. The processor 120 may use any one or any combination of the characteristic points and the internally dividing points to extract features for bio-information estimation. As such, the internally dividing point is calculated from the characteristic points initially extracted from the bio-signal and is used along with the characteristic points to extract additional features that may be used to perform bio-information estimation. Accordingly, it may be possible to obtain a more accurate feature even when the initially extracted characteristic points are extracted from an instable waveform under a non-ideal environment, such as motion noise or sleep.

FIG. 2 is a block diagram illustrating an apparatus for estimating bio-information according to another exemplary embodiment.

Referring to FIG. 2, an apparatus 200 for estimating bio-information includes a bio-signal acquirer 110, a processor 120, a communication interface 210, an output interface 220, and a storage 230.

The bio-signal acquirer 110 may acquire a bio-signal of an object from an external device 250. For example, the bio-signal acquirer 110 may acquire a bio-signal from the external device 250 through the communication interface 210 without being equipped with a bio-signal measurement sensor, such as a PPG sensor. Alternatively, when the bio-signal acquirer 110 is equipped with the bio-signal measurement sensor, such as a PPG sensor, the bio-signal acquirer 110 may selectively use a method of acquiring a bio-signal from the external device 250 under the control of the processor 120 or acquiring a bio-signal by directly driving the bio-signal measurement sensor.

The bio-signal acquirer 110 may perform a preprocessing operation to remove noise from the bio-signal received from the external device 250 and convert the bio-signal into a digital signal, and then may transmit the processed bio-signal to the processor 120.

The processor 120 may generate a control signal to control the bio-signal acquirer 110 in order to acquire the bio-signal. In addition, when the bio-signal is to be acquired from the external device 250, the processor 120 may control the communication interface 210 to be connected to the external device 250.

The apparatus 200 may be connected to the external device 250 through the communication interface 213, using access information of the external device 250 that is included in the control signal. Once the apparatus 200 is connected to the external device 250, the apparatus 200 210 may receive the bio-signal from the external device 250 and then transmit the bio-signal to the bio-signal acquirer 110, through the communication interface 210. In this case, the external device 250 may include a bio-signal measurement sensor to directly measure a bio-signal from the object, or may be a device that receives a bio-signal from a bio-signal measurement device and stores the received bio-signal.

In particular, the communication technology may include a Bluetooth communication, a Bluetooth low energy communication, a near field communication (NFC), a wireless local area network (WLAN) communication, a ZigBee communication, an infrared data association (IrDA) communication, a Wi-Fi direction communication, an ultra-wideband (UWB) communication, Ant+ communication, a Wi-Fi communication, and a mobile communication technology, but is not limited thereto.

When receiving the bio-signal from the bio-signal acquirer 110, the processor 120 may analyze the bio-signal to extract characteristic points and extract features that may be necessary for bio-signal estimation using the extracted characteristic points. In this case, when a waveform of the bio-signal exhibits a non-ideal and unstable form, the processor 120 may calculate internally dividing points using the extracted characteristic points and use the calculated internally dividing points along with the characteristic points to extract features.

When the features are extracted, the processor 120 may estimate bio-information using the extracted feature. In this case, the bio-information may be estimated using a previously constructed bio-information estimation model.

The output interface 220 may output and provide the acquired bio-signal information and various processing results of the processor 120. The output interface 220 may provide the information to the user through various visual/non-visual methods using a display module, a speaker, and a haptic device mounted in the device.

For example, when a blood pressure of the user is estimated, the output interface 220 may output the estimated blood pressure to the user using various visual methods, such as a color, a thickness of a line, a font, and the like, based on whether the estimated blood pressure is within or out of a normal range. Alternatively, the estimated blood pressure may be output by voice or through a non-visual method in which vibration or tactile sensation is changed according to the abnormality of the blood pressure. Alternatively, when it is determined that the estimated blood pressure is abnormal when compared with the recent history of measurement, the user may be warned or advised about actions to be taken by providing, for example, cautionary food information or information about a hospital to be reserved.

The storage 230 may store various pieces of reference information required for bio-information estimation, the obtained bio-signal, the extracted characteristic points and internally dividing points, the extracted features, bio-information estimation results, and the like. In this case, the various pieces of reference information required for bio-information estimation may include user information, such as an age, sex, occupation, current health status, and the like, and the bio-information estimation model information, but is not limited thereto. The storage 230 may include a storage medium of at least one type of a flash memory type, a hard disk type, a multimedia card micro type, a card-type memory (e.g., Secure Digital or eXtreme Digital memory, etc.) a random access memory (RAM), a static random access memory (SRAM), a read-only memory (ROM), an electrically erasable programmable read-only memory (EEPROM), a programmable read-only memory (PROM), a magnetic memory, a magnetic disk, and an optical disk.

Meanwhile, when there is a request from the external device 250 through the communication interface 210, the processor 120 may request the external device 250 to estimate bio-information by transmitting information about at least one of the extracted characteristic points, the internally dividing points, and the extracted feature to the external device 250. However, aspects of the present disclosure are not limited thereto, and when the external device 250 is a device having a relatively better computing performance and equipped with a bio-information estimation function, the external device 250 may request the bio-information estimation by transmitting the characteristic points, internally dividing points, or feature information.

FIG. 3 is a block diagram illustrating the processor according to the exemplary embodiments of FIGS. 1 and 2. FIGS. 4A to 4C are diagrams for describing an exemplary embodiment in which characteristic points are extracted from a bio-signal. FIGS. 5A to 5E are diagrams for describing an exemplary embodiment in which internal dividing points are calculated using the characteristic points of the bio-signal.

An exemplary embodiment in which features necessary for bio-information estimation are extracted through characteristic point extraction, internally dividing point calculation, and the calculated internally dividing points will be described with reference to FIGS. 3 to 5E. Hereinafter, for convenience of description, it will be assumed that an acquired bio-signal is a pulse wave signal and the bio-information to be estimated is blood pressure.

As shown in FIG. 3, a processor 300 includes a characteristic point extractor 310, an internally dividing point calculator 320, a feature extractor 330, and a bio-information estimator 340.

The characteristic point extractor 310 may extract characteristic points using the bio-signal acquired from an object. For example, the characteristic point extractor 310 may extract points associated with component pulses constituting the bio-signal as characteristic points.

Generally, the pulse wave signal acquired from the object may be a summation of a propagation wave propagating from the heart to peripheral parts of a body and reflection waves returning from the peripheral parts of the body. FIG. 4A illustrates a pulse wave signal 40 which is a summation of five component pulses 41, 42, 43, 44, and 45. When information about points associated with each of the component pulses 41, 42, 43, 44, and 45, for example, time and amplitude information may be extracted as characteristic points and the extracted characteristic points are appropriately combined, a feature with high correlation with blood pressure may be extracted. Generally, up to third component pulses are mainly used to estimate blood pressure. Subsequent pulses may not be observed because it may be difficult to detect the subsequent pulses due to noise. Also, the subsequent pulses may have low correlation with blood pressure estimation.

FIG. 4B illustrates an example of extracting points associated with component pulses as characteristic points from a pulse wave signal using a second derivative signal of a bio-signal. Referring to FIG. 4B, when a bio-signal is acquired as shown in (1) BIO-SIGNAL, the characteristic point extractor 310 may derive a second derivative signal by differentiating the bio-signal as shown in (2) SECOND DERIVATIVE SIGNAL, search for local minimum points from the derived second derivate signal as shown in (3) TIME INFORMATION OF LOCAL MINIMUM POINTS, and extract time points T₁, T₂, and T₃ corresponding to the local minimum points as the characteristic points, as shown in (4) AMPLITUDE INFORMATION OF BIO-SIGNAL. In addition, the characteristic point extractor 310 may extract, from the entire bio-signal, amplitudes P₁, P₂, and P₃ corresponding to the time points T₁, T₁, and T₁extracted from the derivative signal as characteristic points. The local minimum point may refer to a specific point of a part of the second derivative signal where the signal decreases and increases again, that is, a point having a downwardly convex shape. For example, the local minimum point may refer to a point of a graph where the graph changes from increasing to decreasing, or the smallest value of the graph within a given range.

In another example, the characteristic point extractor 310 may extract a point in a predetermined region of the bio-signal 40 where the amplitude is the maximum as an additional characteristic point, as shown in FIG. 4C. In this case, the predetermined region of the bio-signal 40 refers to a systolic phase of the blood pressure from the beginning of the bio-signal 40 to the point of the dicrotic notch (DN). The dicrotic notch may refer to an acute drop followed by a rise in blood pressure pulse curves, which appears subsequent to a systolic peak. For example, a position where the bio-signal 40 is curved or bulged downward between time points T₂ and T₃ may correspond to the dicrotic notch. When the bio-signal 40 is acquired, the characteristic point extractor 310 may extract time points T₁,T₂, and T₃ and amplitudes P₁, P₂, and P₃ from each of the three component pulses 41, 42, and 43 constituting the bio-signal 40 as characteristic points, and extract a time point T_(max) and an amplitude P_(max) at a point where the systolic phase of the blood pressure as additional characteristic points. In this case, as described above, the characteristic point extractor 310 may derive a second derivative signal and extract characteristic points by searching for local minimum points of the second derivative signal.

In another example, the characteristic point extractor 310 may extract an area S_(area) of the bio-signal waveform, for example, the whole area or a partial area as characteristic points. At this time, the partial area may mean the area of the bio-signal waveform corresponding to a time region from the beginning to a predetermined ratio (e.g., 70%) based on a time axis of the bio-signal waveform.

In yet another example, the characteristic point extractor 310 may extract, as a characteristic point, a point in a predetermined region of the acquired bio-signal where a first derivative value of the bio-signal is closest to zero, i.e., a point where a slope of a tangent line is closest to zero. Unlike FIG. 4C, in which an amplitude at an extreme point in the systolic region is the maximum, and the like, the acquired bio-signal may not have an ideal waveform. In this case, by extracting, as the characteristic point, the point where the first derivative value of the bio-signal is closest to zero, the characteristic point extractor 310 may accurately estimate blood pressure even in the case where the bio-signal has a non-ideal waveform.

A process in which the characteristic point extractor 310 extracts, as the characteristic point, the point in the predetermined region of the acquired bio-signal where the first derivative value of the bio-signal is closest to zero will be described below with reference to FIG. 4D. FIG. 4D illustrates the acquired bio-signal. In FIG. 4D, a point D where the first derivative value of the bio-signal is closest to zero and a point of the dicrotic notch (DN) are shown. The point D where the first derivative value of the bio-signal is closest to zero and the point of the dicrotic notch (DN) are merely exemplary and are not limited to FIG. 4D.

The predetermined region may refer to a systolic blood pressure region from the beginning of the bio-signal 40 to the point of the dicrotic notch (DN). For example, in FIG. 4D, the predetermined region may refer to a region from the beginning of the bio-signal 40 to the point of the dicrotic notch (DN). However, the predetermined region is not limited thereto, and may refer to a part of the region from the beginning of the bio-signal 40 to the point of the dicrotic notch (DN).

In this case, the characteristic point extractor 310 may extract, as characteristic points, time and amplitude values T_(P) and P_(P) at the point D where the first derivative value of the bio-signal 40 is closest to zero in a time range from the beginning of the bio-signal 40 to the point of the dicrotic notch (DN).

In another example, the characteristic point extractor 310 may detect an inflection point of a second derivative signal of the acquired bio-signal and may extract, as a characteristic point, a point of the bio-signal which corresponds to the detected inflection point of the second derivative signal. That is, the characteristic point extractor 310 may extract, as characteristic points, a time value at the inflection point of the second derivative signal and an amplitude value of the bio-signal which corresponds to the time value.

The inflection point refers to a point at which a waveform changes from a downwardly convex shape to an upwardly convex shape. For example, the characteristic point extractor 310 may acquire a fourth derivative signal by taking the fourth derivative of the bio-signal, may detect a point where a value of a fourth derivative signal is zero, and may calculate a point of the second derivative signal, which corresponds to a time value at the detected point, as the inflection point.

A process in which the characteristic point extractor 310 extracts, as the characteristic point, a point of the bio-signal which corresponds to the calculated inflection point of the second derivative signal will be described below with reference to FIG. 4E. FIG. 4E illustrates a bio-signal and a second derivative signal of the bio-signal. Referring to FIG. 4E, IP denotes the calculated inflection point of the second derivative signal, T_(IP) denotes a time at the inflection point of the second derivative signal, and P_(IP) denotes an amplitude of the bio-signal which corresponds to the time T_(IP). In this case, the characteristic point extractor 310 may extract the point (T_(IP), P_(IP)) as the characteristic point from the bio-signal.

However, examples of the characteristic point extraction of the bio-signal are not limited to the above description, and the characteristic points may be extracted using other various methods.

When the characteristic points are extracted from the bio-signal as described above, the feature extractor 330 may combine the extracted characteristic points to extract features for bio-information estimation. However, if only the points associated with the component pulses are extracted as described, it may be difficult to extract stable characteristic points and feature when noise is contained in the bio-signal waveform or an unstable waveform occurs in a moving environment. Therefore, according to the present exemplary embodiment, the internally dividing point calculator 320 may calculate internally dividing points using the characteristic points extracted by the characteristic point extractor 310, thereby allowing the calculated internally dividing points to be used along with the extracted characteristic points in feature extraction.

FIGS. 5A and 5B are diagrams illustrating examples in which the internally dividing point calculator 320 calculates an internally dividing point in a systolic region. The systolic region may refer to a region between the beginning of an acquired pulse wave signal 51 and the dicrotic notch (DN).

Referring to FIG. 5A, the internally dividing point calculator 320 may calculate an internally dividing point (T_(sys), P_(sys)) between two characteristic points (T₁, P₁) and (T₂, P₂) using the two characteristic points (T₁, P₁) and (T₂, P₂) associated with a component pulse extracted from the systolic region by the characteristic point extractor 310. For example, the internally dividing point calculator 320 may apply weights a and b respectively to each time value T₁ and T₂ of the two characteristic points (T₁, P₁) and (T₂, P₂), and calculate the internally dividing point T_(sys) using each of the time values aT₁, bT₂ to which the weights are applied. For example, the internally dividing point calculator 320 may obtain the internally dividing point T_(sys) by summing the time values aT₁ and bT₂ to which the weights are applied and dividing the sum of the time values by the sum of the weights. Each of the weights a and b may be determined based on the amplitudes P₁ and P₂ of the respective characteristic points, and the internally dividing point T_(sys) may be calculated as shown in Equation 1:

$\begin{matrix} {T_{sys} = {\left( {{P_{1} \times T_{1}} + {P_{2} \times T_{2}}} \right)/\left( {P_{1} + P_{2}} \right)}} & (1) \end{matrix}$

However, the exemplary embodiment is not limited to the above examples, and the weight to be applied to each of the time points may be an arbitrary constant predefined through a preprocessing operation. As such, when the internally dividing point time T_(sys) is determined, it is possible to extract the amplitude P_(sys) at a point of the bio-signal corresponding to T_(sys).

Referring to FIG. 5B, the internally dividing point calculator 320 may calculate an internally dividing point between two characteristic points (T₁, P₂) and (T_(max), P_(max)) using the two characteristic points (T₁, P₁) and (T_(max), P_(max)) extracted from a systolic region of the bio-signal S1. Similarly, the internally dividing point calculator 320 may apply weights respectively to each of the time values T₁ and T_(max) of the two characteristic points (T₁, P₁) and (T_(max), P_(max)) and calculate an internally dividing point T_(sys) using each of the time values to which the weights are applied. For example, the internally dividing point T_(sys) may be calculated as shown in Equation 2:

$\begin{matrix} {T_{sys} = {\left( {{P_{1} \times T_{1}} + {P_{\max} \times T_{\max}}} \right)/\left( {P_{1} + P_{\max}} \right)}} & (2) \end{matrix}$

The exemplary embodiment of FIG. 5B is useful when a waveform of the bio-signal S1 is not ideal and exhibits instability. For example, in the case of an abnormal waveform, a waveform component corresponding to the second characteristic point (T₁, P₂) may not be accurately observed. In this case, instead of the second characteristic point (T₂, P₂), a characteristic point (T_(max), P_(max)) at which the amplitude is the maximum in the systolic region may be used to obtain an internally dividing point (T_(sys), P_(sys)) robust to the abnormal waveform. In addition, in a case where a waveform of the bio-signal is unstable, a value of P₁ of the first characteristic point in an environment where characteristic points are continuously measured may be suddenly observed as a very small value. Even in this case, if an amplitude value P_(max) at a point where the amplitude is the maximum in the systolic region is maintained constant, by giving a weight based on the amplitude values P₁ and P_(max), a robust internally dividing point (T_(sys), P_(sys)) may be obtained in spite of the instability of the characteristic point (T₁, P₁).

In another example, the internally dividing point calculator 320 may determine whether a condition for calculating the internally dividing point in the systolic region is satisfied, and upon determining that the condition is satisfied, the internally dividing point calculator 320 may calculate the internally dividing point in the systolic region.

A process of determining whether the condition for calculating the internally dividing point is satisfied will be described below with reference to FIG. 4E. FIG. 4E illustrates a bio-signal and a second derivative signal of the bio-signal. Referring to FIG. 4E, Ta denotes a time value at a first local maximum point of the second derivative signal of the bio-signal, Tb denotes a time value at a first local minimum point of the second derivative signal of the bio-signal, and IP denotes the detected inflection point of the second derivative signal of the bio-signal, as described above.

The internally dividing point calculator 320 may determine whether the condition for calculating the internally dividing point is satisfied based on the presence of the inflection point of the second derivative signal of the bio-signal in a predetermined time range.

In this case, the predetermined time range may refer to a time range (Ta to Tb) from the first local maximum point of the second derivative signal of the bio-signal to the first local minimum point thereof, or a portion of the time range (e.g., Ta+(2/5)*(Tb−Ta) to Tb), but is not limited thereto. As described above, the inflection point refers to a point at which the waveform changes from a downwardly convex shape to an upwardly convex shape.

Referring to FIG. 4E, assuming that the predetermined time range is from Ta to Tb, there is the inflection point IP detected in the time range of Ta to Tb, such that the internally dividing point calculator 320 may determine that the condition for calculating the internally dividing point in the systolic region is satisfied.

Referring back to FIG. 3, if the condition for calculating the internally dividing point in the systolic region is satisfied, the internally dividing point calculator 320 may calculate the internally dividing point between the detected inflection point and one of a plurality of characteristic points extracted by the characteristic point extractor 310. In this case, the plurality of characteristic points may include the points associated with component pulses, the point in the systolic region of the bio-signal where the amplitude is the maximum, the point in the predetermined region of the bio-signal where the first derivative value is closest to zero, and the like.

For example, the internally dividing point calculator 320 may calculate an internally dividing point between the inflection point, detected in a predetermined time range, and the first characteristic point. In this case, the first characteristic point may include the point in the systolic region of the bio-signal where the amplitude is the maximum, or the point in the predetermined region of the bio-signal where the first derivative value is closest to zero, but is not limited thereto.

For example, the internally dividing point calculator 320 may calculate the internally dividing point between the point (T_(P), P_(P)) in the predetermined region of the bio-signal of FIG. 4D, at which the first derivative value is closest to zero, and the point (T_(IP), P_(IP)) of the bio-signal of FIG. 4E which corresponds to the detected inflection point of the second derivative signal of the bio-signal. However, the internally dividing point is not limited thereto, and the internally dividing point calculator 320 may also calculate, for example, an internally dividing point between the point (T_(max), P_(max)) in the systolic region of the bio-signal of FIG. 4C, at which the amplitude is the maximum, and the point (T_(IP), P_(IP)) of the bio-signal of FIG. 4E which corresponds to the detected inflection point of the second derivative signal of the bio-signal.

In this case, the internally dividing point calculator 320 may apply weights a and b respectively to each time value T_(IP) and T_(P) of two characteristic points, e.g., points (T_(IP), P_(IP)) and (T_(P), P_(P)), and calculate the internally dividing point using each of the weighted time values aT₁ and bT₂. For example, the internally dividing point calculator 320 may calculate the internally dividing point by adding up the weighted time values aT₁ and bT₂ and by dividing the sum of the time values by the sum of the weights. In this case, each of the weights a and b may be determined based on the amplitudes P_(IP) and P_(P) of the respective characteristic points. In this case, each of the weights a and b, which are applied to the respective time values, may be an arbitrary constant predefined through a preprocessing operation. As described above, upon determining the time of the internally dividing point, the internally dividing point calculator 320 may extract an amplitude, corresponding to the time of the internally dividing point, from the bio-signal.

If the condition for calculating the internally dividing point in the systolic region is not satisfied, the internally dividing point calculator 320 may not calculate the internally dividing point in the systolic region.

In this case, the feature extractor 330 may extract, as features, the time and amplitude of the second characteristic point itself extracted from the bio-signal. In this case, the second characteristic point may refer to a first local minimum point of the second derivative signal of the bio-signal, e.g., (T₁, P₁) of FIG. 4C, which is one of the points associated with component pulses of the bio-signal. However, the second characteristic point is not limited thereto, and may be any other one of the characteristic points extracted by the characteristic point extractor 310.

FIGS. 5C to 5E are diagrams for describing an exemplary embodiment in which an internally dividing point in the diastolic region is calculated. The diastolic region may refer to a region of a bio-signal after dicrotic notch (DN).

Referring to FIG. 5C, the characteristic point extractor 310 may extract a point (T₃, P₃), which is a point associated with the third component pulse, as a representative characteristic point in the diastolic region of a pulse wave signal 52. This characteristic point increases in instability relative to a characteristic point extracted from the diastolic region due to various noises generated. According to the present exemplary embodiment, the internally dividing point calculator 320 may calculate an internally dividing point by utilizing a characteristic point of another component pulse in the systolic region.

For example, as shown in FIG. 5C, when it is assumed that generally the third component pulse associated with the characteristic point (T₃, P₃) is a waveform component having the largest maximum amplitude in the diastolic region of a bio-signal, a characteristic point (T₄, P₄) associated with a waveform component having an amplitude greater than an amplitude of the amplitude P₃, for example, a waveform component of the fourth component pulse in the diastolic region may be extracted in the case of a specific bio-signal waveform. In this case, physiologically, the characteristic point (T₃, P₃) associated with the third component pulse may not be given great significance. At this point, the internally dividing point calculator 320 may calculate an internally dividing point (T_(dia), P_(dia)) of the characteristic points (T₃, P₃) and (T₄, P₄) extracted from the diastolic region. The internally dividing point calculator 320 may apply weights respectively to each of the time points T₃ and T₄ based on each of the amplitudes P₃ and P₄, and calculate the internally dividing point (T_(dia), P_(dia)) in the diastolic region based on the time values to which the weights are applied. For example, the internally dividing point (T_(dia), P_(dia)) may be calculated as shown in Equation 3:

$\begin{matrix} {T_{dia} = {\left( {{P_{3} \times T_{3}} + {P_{4} \times T_{4}}} \right)/\left( {P_{3} + P_{4}} \right)}} & (3) \end{matrix}$

Meanwhile, the internally dividing point calculator 320 may determine whether a preset condition of calculating the internally dividing point in the diastolic region is satisfied, and, when the condition is satisfied, may calculate the internally dividing point. In this case, the condition for calculating the internally dividing point in the diastolic region may be satisfied when the value of P₃ is smaller than the value of P₄. When it is determined that the value of P₃ is greater than the value of P₄, the characteristic point (T₃, P₃) extracted from the third component pulse may be used as is. However, the condition for calculating the internally dividing point is not limited to the above description, and the condition may include a case where a difference between P₃ and P₄ is not greater than an arbitrary number, a case where a difference between P₃ and P₄ is greater than an arbitrary number, or the like.

In another example, the internally dividing point calculator 320 may calculate the internally dividing point based on an n-order derivative signal of the bio-signal in the diastolic region. The characteristic point extractor 310 may search for local minimum points of a second derivative signal by second order differentiating the bio-signal and extract characteristic points associated with component pulses, as described above. In this case, if the bio-signal has been acquired in a non-ideal environment and thus the waveform of the bio-signal is unstable, the second derivative signal may also fluctuate unstably. For example, the local minimum point of the second derivative signal corresponding to the representative characteristic point (T₃, P₃) of the diastolic region does not appear at the physiologically correct position, and the local minimum point of the second derivative signal may unsteadily fluctuate back and forth around the corresponding position.

In this case, the internally dividing point calculator 320 may calculate an internally dividing point of characteristic points extracted from two local minimum points of the second derivative signal in order to alleviate the instability of the second derivative signal. The internally dividing point calculator 320 may apply a weight to each of the time values of the characteristic points based on a difference between the amplitude of each of the local minimum points of the second derivative signal and the amplitude at a predetermined point of the second derivative signal, and calculate the internally dividing point using each of the time values to which the weights are applied, as described above.

For example, referring to FIG. 5D, a difference W₁ between the amplitude of T₃, which is a local minimum point of a diastolic region of a second derivative signal 54, and the amplitude of a local maximum point L₄, which appears immediately before T₄, may be determined as a weight to be applied to the time value T₃ of a characteristic point in the diastolic region. In addition, a difference W₂ between the amplitude of T₄, which is a local minimum point, and the amplitude of L₄, which is a local maximum point, may be determined as a weight of the time value T₄ of a characteristic point of the diastolic region. The time value T₁ may be referred to as a third local minimum point given that the time value T₃ is a local minimum point that thirdly appears in the diastolic region of the second derivative signal 54. The time value T₄ may be referred to as a fourth local minimum point given that the time value T₄ is a local minimum point that fourthly appears in the diastolic region of the second derivative signal 54.

According to the exemplary embodiment of FIG. 5D, the internally dividing point (T_(dia), P_(dia)) may be calculated as shown in Equation 4:

$\begin{matrix} {T_{dia} = {\left( {{W_{1} \times T_{3}} + {W_{2} \times T_{4}}} \right)/\left( {W_{1} + W_{2}} \right)}} & (4) \end{matrix}$

FIG. 5E shows an example in which differences between the amplitude of T₁ and the amplitude of L₃ and between the amplitude of T₄ and the amplitude of L₃ are determined as weights W₁ and W₂ to be applied respectively to time values T3 and T4 of characteristic points of the diastolic region.

Meanwhile, the internally dividing point calculator 320 may determine whether a condition for calculating an internally dividing point is satisfied based on at least one of the weights W₁ and W₂, which are obtained based on the second derivative signal, and when the condition is satisfied, may calculate the internally dividing point. For example, only when the weight W₁ to be applied to the first characteristic point (T₃, P₃) in the diastolic region is smaller than a predetermined threshold, the internally dividing point may be calculated. If the weight W₁ is greater than or equal to the predetermined threshold, the first characteristic point (T₃, P₃) may be used as is without the weight W₁ being applied. However, the exemplary embodiment is not limited thereto, and the condition for calculating the internally dividing point may include various conditions, such as a case where the W₂ to be applied to the second characteristic point (T₄, P₄) in the diastolic region is greater than a predetermined threshold.

Once the characteristic points and the internally dividing points are obtained, the feature extractor 330 may determine information to be used in feature extraction among the obtained characteristic points and internally dividing points, and extract features necessary for bio-information extraction by combining the determined information.

For example, it is assumed that (T₁, P₁), (T₃, P₃), (T₄, P₄), (T_(max), P_(max)), and S_(are) are extracted by the characteristic point extractor 310. In addition, it is assumed that an internally dividing point (T_(sys), P_(sys)) between the characteristic points (T₁, P₁) and (T_(max), P_(max)) and an internally dividing point (T_(dia), P_(dia)) between the characteristic points (T₃, P₃) and (T₄, P₄) are calculated. In this case, through an analysis of bio-signal waveform, second derivative signal waveform, and component pulses, the feature extractor 330 may determine the calculated internally dividing points (T_(sys), P_(sys)) and (T_(dia), P_(dia)), the characteristic point (T_(max), P_(max)), and S_(area) as information to be used in feature extraction. In addition, the feature extractor 330 may acquire two features f₁ and f₂ as shown in Equation 5 below by combining the determined information.

$\begin{matrix} {{f_{1} = {P_{\max}/S_{area}}}{f_{2} = {1/\left( {T_{dia} - T_{sys}} \right)}}} & (5) \end{matrix}$

However, the features are merely examples, and are not limited thereto. For example, the first feature f₁ is a feature related to the cardiac output, and it may further include, such as, P_(max)/P_(area), P_(max)/P₃, P_(sys)/P₃, P₁/P₃, P₂/P₃, 1/T_(period), or the like. The second feature f₂ is a feature related to the total peripheral vascular resistance, and it may further include 1/(T₃−T_(sys)), 1/(T₃−T_(max)), 1/(T₃−T₁), 1/(T₃−T₂), P₃/P₁, P₂/O₁, or the like. Here, P_(area) denotes the sum of amplitudes of the bio-signal for a predefined time interval (e.g. between time 0 and τ_(dur)*T_(period)). T_(period) denotes a period of the bio-signal. τ_(dur) denotes a predefined setting factor (0≤τ_(dur)≤1) (e.g., 0.7).

When the feature extractor 320 extracts the features, the bio-information estimator 340 may estimate bio-information using the extracted features. For example, blood pressure may be estimated by applying the features extracted as shown in the above Equation 5 to a blood pressure estimation equation as shown in Equation 6 below.

$\begin{matrix} {{BP} = {{A\left( {f_{1} + {wf}_{2}} \right)} + B}} & (6) \end{matrix}$

Here, BP denotes an estimated blood pressure, and A, w, and B denote arbitrary coefficients.

FIG. 6A is a flowchart illustrating a method of estimating bio-information according to one exemplary embodiment.

FIG. 6A shows an exemplary embodiment of a method of estimating bio-information which is performed by the apparatus 100 for estimating bio-information according to the exemplary embodiment of FIG. 1, which has been described in detail with reference to FIGS. 1 to 5E, and thus the method will be described in brief to avoid unnecessary repetition.

First, the apparatus 100 for estimating bio-information receives a request for bio-information estimation, in operation 610. The apparatus 100 may provide an interface to perform various interactions with a user. The user may request the bio-information estimation through the interface provided by the apparatus 100.

Alternatively, the apparatus 100 may receive a request for bio-information estimation from an external device. In this case, the request for bio-information estimation received from the external device may include a request for providing a bio-information estimation result. When the external device is equipped with a bio-information estimation algorithm, the request for bio-information estimation may include a request for providing characteristic point or feature information. The external device may include a smartphone or a tablet PC that the user carries, and the user may control the apparatus 100 through a portable device having superior interface performance and computing performance to those of the apparatus 100 for bio-information estimation.

Then, the apparatus 100 acquires a bio-signal for bio-information estimation, in operation 620. For example, the apparatus 100 may control a bio-signal measurement sensor (e.g., a PPG sensor) to measure a pulse wave signal, and acquire a pulse wave signal from an object. In another example, when the apparatus 100 does not include the bio-signal measurement sensor, the apparatus 100 may receive a bio-signal from an external bio-signal measurement device.

Then, a plurality of characteristic points may be extracted from the acquired bio-signal, in operation 630. As described above, the apparatus 100 may extract points associated with component pulses constituting the acquired bio-signal as the characteristic points. For example, the apparatus 100 may acquire a second derivative signal of a pulse wave signal acquired for estimating blood pressure, and extract information about time and amplitude of a local minimum point of the second derivative signal as a characteristic point associated with a component pulse. In addition, the apparatus 100 may extract time and amplitude information at a point where the amplitude is the maximum in a systolic phase of blood pressure as an additional characteristic point in order to compensate the case where the pulse wave signal is unstable due to noise, motion, or the like. Also, the apparatus 100 may extract the whole area or a partial area of the pulse wave signal as an additional characteristic point.

Thereafter, internally dividing points of two or more characteristic points are calculated, in operation 640. For example, the apparatus 100 may calculate an internally dividing point for each of the systolic region and the diastolic region of the pulse wave signal. Two time values extracted from the pulse wave signal may be given weights and an internally dividing point may be calculated using the time values to which the weights are applied. In this case, the weights may be determined based on the amplitude values of two characteristic points. For example, the internally dividing point may be calculated by dividing the sum of the time values to which the weights are applied by the sum of the weights. Meanwhile, when the plurality of characteristic points are extracted, the apparatus 100 may check various preset conditions for calculating an internally dividing point, and may use the extracted characteristic points intact when the conditions are not satisfied.

Then, the apparatus 100 extracts features necessary for bio-information estimation using the extracted characteristic points and internally dividing points, in operation 650. In this case, the features necessary for bio-information estimation may be extracted by combining two or more characteristic points and internally dividing points as shown in Equation 5.

Hereinafter, operations 630 to 650 are described with references to FIGS. 6B and 6C in greater detail.

As shown in FIG. 6B, the apparatus 100 may extract characteristic points (T₁, P₁), (T₂, P₂), and (T_(max), P_(max)) from the systolic region of the pulse wave signal, in operation 630 a. In turn, the apparatus 10 may calculate a first internally dividing point T_(sys1) according to equation 1 in operation 640 a, and may calculate a second internally dividing point T_(sys2) according to equation 2 in operation 640 b. The apparatus 100 may perform either operation 640 a or operation 640 b, or both of the operations 640 a and 640 b. Then, the apparatus 100 may extract features based on the first internally dividing point T_(sys1) and the second internally dividing point T_(sys2) in operations 650 a and 650 b, respectively.

As shown in FIG. 6C, the apparatus 100 may extract characteristic points (T₃, P₃) and (T₄, P₄) from the diastolic region of the pulse wave signal, in operation 630 b. If the apparatus 100 determines that the amplitude P₄ is greater than the amplitude P₃ in operation 640 c, the apparatus 100 may calculate a first internally dividing point T_(dia1) for the diastolic region according to Equation 3, in operation 640 e, and extract a feature based on T_(dia1) in operation 650 d. On the other hand, if the apparatus 100 determines that the amplitude P₄ is less than or equal to the amplitude P₃ in operation 640 c, the apparatus 100 may extract a feature based on the characteristic point (T₃, P₃).

Alternative to operations 640 c, 640 e, and 650 b, the apparatus 100 may determine whether a difference W₁ between the amplitude at a local minimum point T₃ of the second derivative signal 54 and the amplitude at a local maximum point L₄ immediately before T₄ is less than a predetermined threshold, in operation 640 d. In another example, the different W1 may correspond to the difference between the amplitude at T₃ and the amplitude at a local maximum point L₃ immediately before T₄. In operation 640 f, the apparatus 100 may calculate a second internally dividing point T_(dia2) for the diastolic region according to Equation 4, and then in operation 650 e, the apparatus 100 may extract a feature based on the second internally dividing point T_(dia2). However, if the apparatus 100 determines that the difference W₁ is equal to or greater than the predetermined threshold in operation 640 d, the apparatus 100 may extract a feature based on the characteristic point (T₃, P₃) instead of the second internally dividing point T_(dia2) in operation 650 f.

Operations 630 a, 640 a, 640 b, 650 a, and 650 b shown in FIG. 6B, and operations 630 b, 640 c-640 f, and 650 d-650 f shown in FIG. 6c may be performed in parallel or in sequence.

Then, the apparatus 100 estimates bio-information using the extracted features, in operation 660. In this case, a bio-information estimation model may be constructed in advance. The bio-information estimation model may be a mathematical equation as shown in Equation 6. When the features are extracted, the apparatus 100 may estimate the bio-information by applying the extracted feature information to the bio-information estimation model.

Then, the apparatus 100 provides a bio-information estimation result to the user, in operation 670. At this time, the apparatus 100 may provide the estimated bio-information to the user using various visual/non-visual methods. In addition, the apparatus 100 may determine the user's health status based on the estimated bio-information, and provide warning or an advice on actions to be taken to the user according to the determination result.

FIGS. 7A to 7D are diagrams for describing a wearable device according to one exemplary embodiment. Various exemplary embodiments of the above-described apparatus for estimating bio-information may be mounted in a smartwatch or smart band-type wearable device worn on a wrist. However, this is merely an example for convenience of description, and the exemplary embodiments should not be construed as being limited to being applied to a smart watch or smart band-type wearable device.

Referring to FIGS. 7A to 7D, a wearable device 700 includes a device main body 710 and a strap 720.

The strap 720 may be configured to be flexible and bent in such a manner that is wrapped around the wrist of the user or separated from the wrist. Alternatively, the strap 720 may be configured in a non-separable band form. In this case, the strap 720 may be filled with air or an air bag so as to have elasticity according to a change in pressure applied to the wrist, and may transmit a pressure change of the wrist to the main body 710.

A battery may be equipped in the main body 710 or the strap 720 to supply power to the wearable device.

In addition, the wearable device 700 may include, inside the main body 710, a measurer 711 configured to measure a bio-signal by emitting light to an object OBJ and detecting scattered light returning from the object OBJ, and a processor 712 configured to detect bio-information of the user using the bio-signal measured by the measurer 711.

The measurer 711 may be mounted on a lower portion of the main body 710, that is, a portion that comes in contact with the object OBJ, for example, the user's wrist, and may include a light source 711A configured to emit light to the object OBJ and a detector 711B configured to detect light emitted from the object OBJ according to a control signal of the processor 712.

In addition, the measurer 711 may further include a contact pressure sensor configured to measure a contact pressure of the object OBJ. The contact pressure sensor may measure the contact pressure of the object OBJ transferred to the main body 710 through the strap 720 that secures the main body to the object OBJ in a manner that is wrapped around the wrist.

The processor 712 may generate the control signal to control the measurer 711. In addition, the processor 712 may receive bio-signal data measured by the measurer 711 and estimate bio-information using the bio-signal data.

For example, the processor 712 may extract a plurality of characteristic points from the bio-signal as described above. In this case, the plurality of characteristic points may be extracted from points associated with component pulses of the bio-signal. In addition, a point where the amplitude is the maximum within a predetermined region of the bio-signal or an area of the bio-signal may be extracted as characteristic points.

When the plurality of characteristic points are extracted from the bio-signal, the processor 712 may calculate internally dividing points of two or more characteristic points and extract features using the calculated internally dividing points and the characteristic points. The processor 712 may determine characteristic points to be used to calculate the internally dividing points according to a preset criterion for calculating the internally dividing points, apply weights to time values of two or more determined characteristic points, and calculate the internally dividing points based on the time values to which the weights are applied. In this case, the weights respectively applied to each of the time values may be determined based on amplitude values of each of the two or more determined characteristic points.

When the contact pressure sensor is equipped in the measurer 711 and measures a contact pressure signal of the object, the processor 712 may guide the user to change the contact pressure applied to the wrist based on the measured contact pressure signal.

The processor 712 may manage estimated bio-information, for example, blood pressure history information, bio-information used to measure various blood pressures, and component pulses decomposed from the bio-information in a storage device. Also, the processor 712 may generate additional information, such as alarm or warning information related to estimated bio-information, a change in health status, and the like, which is necessary for user's healthcare and manage the generated information in the storage device.

In addition, the wearable device 700 may further include an operator 715 and a display 714, which are mounted in the main body 710.

The operator 715 may receive a control instruction of the user, transmit the control instruction to the processor 712, and include a power button to enable the user to input an instruction for power on/off of the wearable device 700.

The display 714 may provide a variety of information related to the detected bio-information under the control of the processor 712. For example, the display 714 may display additional information, such as measured blood pressure, alarm, or warning information, to the user in various visual/non-visual ways.

For example, referring to FIGS. 7B and 7C, when blood pressure is estimated according to a user's request, the display 714 may display estimated blood pressure information as shown in FIG. 7B. Also, when the user requests detailed information by controlling the operator 715 or touching the display 714, the display 714 may display the detailed information as shown in FIG. 7C. For example, as shown in FIG. 7C, the display 714 may include a first area 714 b and a second area 714 a. The estimated blood pressure information may be displayed in the first area 714 b, as shown in FIG. 7B. Alternatively, as shown in FIG. 7C, the change in blood pressure may be displayed in the form of a graph.

The display 714 may display a mark M that indicates currently selected blood pressure information I in the first area 714 b. In FIG. 7C, the mark M is shown as a vertical line, but is not limited thereto, and the mark M may be displayed in various forms, such as a polygon, such as a circle, a rectangle, and the like, and an arrow indicating a position of the selected blood pressure information. When the change in blood pressure is displayed in the first area 714 b, the user may touch and select desired blood pressure information or select the desired blood pressure information by moving the graph to the left and right to align the desired blood pressure information to the mark M. When the user selects the blood pressure information in the first area 714 b, blood pressure information, extracted feature information, and the like may be displayed near the selected blood pressure information.

In addition, when the user selects any blood pressure information in the first area 714 b, the display 714 may display a bio-signal used to estimate the selected blood pressure information I in response to the user's selection, and component pulses constituting the bio-signal in the second area 714 a. In addition, extracted characteristic points may be displayed on the bio-signal shown in the second area 714 a. By doing so, the user may easily grasp the change of the blood pressure and intuitively understand the bio-signal and a variety of information extracted from the bio-signal according to the change of the blood pressure.

In addition, the main body 710 may further include a communication interface 713 in an internal space so as to communicate with an external device, such as a portable terminal of the user.

The communication interface 713 may communicate with the external device of a user which has a relatively better computing performance and transmit and receive necessary information under the control of the processor 712. For example, the communication interface 713 may receive a request for estimating bio-information from the user's portable terminal. In addition, the communication interface 713 may transmit extracted characteristic points or feature information to the external device to request estimation of bio-information. Further, the communication interface 713 may transmit a bio-information estimation result to the external device so as to be displayed to the user or to be utilized for various purposes, such as bio-information history management and disease research.

While not restricted thereto, an exemplary embodiment can be embodied as computer-readable code on a computer-readable recording medium. The computer-readable recording medium is any data storage device that can store data that can be thereafter read by a computer system. Examples of the computer-readable recording medium include read-only memory (ROM), random-access memory (RAM), CD-ROMs, magnetic tapes, floppy disks, and optical data storage devices. The computer-readable recording medium can also be distributed over network-coupled computer systems so that the computer-readable code is stored and executed in a distributed fashion. Also, an exemplary embodiment may be written as a computer program transmitted over a computer-readable transmission medium, such as a carrier wave, and received and implemented in general-use or special-purpose digital computers that execute the programs. Moreover, it is understood that in exemplary embodiments, one or more units of the above-described apparatuses and devices can include circuitry, a processor, a microprocessor, etc., and may execute a computer program stored in a computer-readable medium.

The foregoing exemplary embodiments are merely exemplary and are not to be construed as limiting. The present teaching can be readily applied to other types of apparatuses. Also, the description of the exemplary embodiments is intended to be illustrative, and not to limit the scope of the claims, and many alternatives, modifications, and variations will be apparent to those skilled in the art. 

What is claimed is:
 1. An apparatus for estimating bio-information, the apparatus comprising: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to extract a plurality of characteristic points from the bio-signal, determine internally dividing points of the plurality of characteristic points, and extract feature values from the bio-signal based on the internally dividing points to perform bio-information estimation.
 2. The apparatus of claim 1, wherein the processor comprises an internally dividing point calculator configured to apply weights respectively to time values of the plurality of characteristic points and calculate the internally dividing points of the plurality of characteristic points based on the time values to which the weights are applied.
 3. The apparatus of claim 2, wherein the internally dividing point calculator is further configured to calculate the internally dividing points of the plurality of characteristic points based on a sum of the weights.
 4. The apparatus of claim 2, wherein the internally dividing point calculator is further configured to apply the weights respectively to the time values based on amplitude values of the plurality of characteristic points.
 5. The apparatus of claim 2, wherein the internally dividing point calculator is further configured to calculate the weights based on differences between first amplitudes at a plurality of points in a derivative signal of the bio-signal and a second amplitude at a predetermined point in the derivative signal, and wherein the plurality of points in the derivative signal correspond to the plurality of characteristic points extracted from the bio-signal.
 6. The apparatus of claim 1, wherein the processor comprises a bio-information estimator configured to estimate bio-information comprising at least one of blood pressure, vascular age, arterial stiffness, aortic pressure waveform, stress index, and fatigue based on the extracted feature values.
 7. The apparatus of claim 1, wherein the processor comprises a characteristic point extractor configured to extract, as the plurality of characteristic points, at least one of points associated with component pulses constituting the bio-signal, a point at which an amplitude has a maximum value in a systolic region of the bio-signal, an area of the bio-signal, and a point in a predetermined region of the bio-signal where a first derivative value is closest to zero.
 8. The apparatus of claim 7, wherein the characteristic point extractor is further configured to determine local minimum points in a second derivative signal of the bio-signal as the points associated with the component pulses.
 9. The apparatus of claim 7, wherein the processor further comprises a feature extractor configured to extract the feature values based on at least one of a ratio of the area of the bio-signal to an amplitude value at the point at which an amplitude has the maximum value in the systolic region of the bio-signal and a difference in time value between the internally dividing points acquired from each of the systolic region and a diastolic region of the bio-signal.
 10. The apparatus of claim 1, wherein the bio-signal acquirer comprises a photoplethysmogram (PPG) sensor configured to emit a light to an object and acquire a PPG signal by detecting the light reflected or scattered from the object.
 11. The apparatus of claim 1, further comprising a communication interface configured to receive a photoplethysmogram (PPG) signal from an external device and transmit the PPG signal to the bio-signal acquirer.
 12. A method of estimating bio-information, the method comprising: acquiring a bio-signal; extract a plurality of characteristic points from the bio-signal; determining internally dividing points of the plurality of characteristic points; and extracting feature values from the bio-signal based on the internally dividing points to perform bio-information estimation.
 13. The method of claim 12, wherein the determining the internally dividing points comprises applying weights respectively to time values of the plurality of characteristic points and calculating the internally dividing points of the plurality of characteristic points based on the time values to which the weights are applied.
 14. The method of claim 13, wherein the determining the internally dividing points comprises calculating the internally dividing points of the plurality of characteristic points based on a sum of the weights.
 15. The method of claim 14, wherein the determining the internally dividing points comprises applying the weights respectively to the time values based on amplitude values of the plurality of characteristic points.
 16. The method of claim 14, wherein the determining the internally dividing points comprises applying the weights respectively to the time values based on differences between first amplitudes at a plurality of points in a derivative signal of the bio-signal and a second amplitude at a predetermined point in the derivative signal, and wherein the plurality of points in the derivative signal correspond to the plurality of characteristic points extracted from the bio-signal.
 17. The method of claim 12, further comprising estimating the bio-information, which comprises at least one of blood pressure, vascular age, arterial stiffness, aortic pressure waveform, stress index, and fatigue, based on the extracted feature values.
 18. The method of claim 12, further comprising extracting, as the plurality of characteristic points, at least one of points associated with component pulses constituting the bio-signal, a point at which an amplitude has a maximum value in a systolic region of the bio-signal, an area of the bio-signal, and a point in a predetermined region of the bio-signal where a first derivative value is closest to zero.
 19. The method of claim 18, wherein the extracting of the plurality of characteristic points includes determining local minimum points in a second derivative signal of the bio-signal as the points associated with the component pulses.
 20. The method of claim 18, wherein the extracting the feature values comprises extracting the feature values based on at least one of a ratio of the area of the bio-signal to an amplitude value at the point at which an amplitude has the maximum value in the systolic region of the bio-signal and a difference in time value between the internally dividing points acquired from each of the systolic region and a diastolic region of the bio-signal.
 21. The apparatus of claim 1, wherein the bio-signal acquirer comprises a light source configured to emit a light to an object and a detector configured to detect the light scattered or reflected from the object, and wherein the bio-signal acquirer acquires the bio-signal from the light detected by the detector.
 22. A blood pressure monitoring device, comprising: a light emitter configured to emit a light to a subject; a light detector configured to detect the light that is scattered, deflected, or reflected from the subject to obtain a pulse wave signal from the detected light; a processor configured to extract a plurality of characteristic points from the pulse wave signal, determine amplitude values corresponding to the plurality of characteristic points from the pulse wave signal, determine an internally dividing point of the plurality of characteristic points based on the amplitude values and the plurality of characteristic points, and determine a blood pressure of the subject based on the internally dividing point of the pulse wave signal.
 23. The blood pressure monitoring device of claim 22, wherein the processor is further configured to: extract a first time point T₁ and a second time point T₂ from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a first component pulse wave that has a maximum amplitude at the first time point T₁, and a second component pulse wave that has a maximum amplitude at the second time point T₂; determine a first amplitude P₁ and a second amplitude P₂ of the pulse wave signal corresponding to the first time point T₁ and the second time point T₂, respectively; and determine the internally dividing point based on the first time point T₁, the second time point T₂, the first amplitude P₁, and the second amplitude P₂.
 24. The blood pressure monitoring device of claim 22, wherein the processor is further configured to: extract a first time point T₁ and a maximum time point T_(max) from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a first component pulse wave that has a maximum amplitude at the first time point T₁, and the pulse wave signal has a maximum amplitude P_(max) at the maximum time point T_(max); determine a first amplitude P₁ of the pulse wave signal corresponding to the first time point T₁; and determine the internally dividing point based on the first time point T₁, the maximum time point T_(max), the first amplitude P₁ and the maximum amplitude P_(max).
 25. The blood pressure monitoring device of claim 22, wherein the processor is further configured to: extract a third time point T₃ and a fourth time point T₄ from the pulse wave signal, as the plurality of characteristic points, when the pulse wave signal comprises a third component pulse wave that has a maximum amplitude at the third time point T₃, and a fourth component pulse wave that has a maximum amplitude at the fourth time point T₄; determine a third amplitude P₃ and a fourth amplitude P₄ of the pulse wave signal corresponding to T3 and T4, respectively; and determine the internally dividing point based on the third time point T₃, the fourth time point T₄, the third amplitude P₃, and the fourth amplitude P₄, in response to the fourth amplitude P₄ being greater than the third amplitude P₃.
 26. The blood pressure monitoring device of claim 22, wherein the processor is further configured to: extract a third local minimum point T_(local3) and a fourth local minimum point T_(local4) from a second derivative signal of the pulse wave signal; extract, from the second derivative signal, a third local maximum point L₃ that appears prior to the third local minimum point T_(local3), and a fourth local maximum point L₄ that appears between the third local minimum point T_(local3) and the fourth local minimum point T_(local4); and determine a first difference W₁ between an amplitude at the third local minimum point T_(local3) and an amplitude at the fourth local maximum point L₄; determine a second difference W₂ between the amplitude at the fourth local maximum point L₄ and an amplitude at the fourth local minimum point T_(local4); and determine the internally dividing point based on the third local minimum point T_(local3), the fourth local minimum point T_(local4), the first difference W₁, and the second difference W₂.
 27. The blood pressure monitoring device of claim 22, wherein the processor is further configured to: extract a third local minimum point T_(local3) and a fourth local minimum point T_(local4) from a second derivative signal of the pulse wave signal; extract, from the second derivative signal, a third local maximum point L₃ that appears prior to the third local minimum point T_(local3), and a fourth local maximum point L₄ that appears between the third local minimum point T_(local3) and the fourth local minimum point T_(local4); and determine a first difference W₁ between an amplitude at the third local maximum point L₃ and an amplitude at the third local minimum point T_(local3); determine a second difference W₂ between the amplitude at the third local maximum point L₃ and the amplitude at the fourth local minimum point T_(local4); and in response to the first difference W₁ being less than a predetermined threshold value, determine the internally dividing point based on the third local minimum point T_(local3), the fourth local minimum point T_(local4), the first difference W₁, and the second difference W₂.
 28. An apparatus for estimating bio-information, the apparatus comprising: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to determine whether there is an inflection point in a predetermined time range of a second derivative signal of the acquired bio-signal, and upon determining that there is the inflection point, configured to calculate an internally dividing point between the inflection point and a first characteristic point extracted from the bio-signal, and to extract features for bio-information estimation based on the calculated internally dividing point.
 29. The apparatus of claim 28, wherein in response to there being no inflection point in the predetermined time range, the processor extracts the features for bio-information estimation based on a second characteristic point extracted from the bio-signal.
 30. The apparatus of claim 29, wherein: the first characteristic point comprises a point in a systolic region of the bio-signal where an amplitude has a maximum value, or a point in a predetermined region of the bio-signal where a first derivative value is closest to zero; and the second characteristic point comprises a first local minimum point of the second derivative signal of the bio-signal.
 31. The apparatus of claim 28, wherein the time range is at least a portion of a time range from a first local maximum point of the second derivative signal of the bio-signal to a first local minimum point of the second derivative signal of the bio-signal. 